Electrospun scaffolds for wound healing applications from poly(4?hydroxybutyrate): A biobased and biodegradable linear polymer with high elastomeric properties

Electrospun scaffolds of the biodegradable and biocompatible poly-4-hydroxybutyrate (P4HB) polyester have been prepared using horizontal vertical set-up configurations electrospinning. Specifically, it has evaluated influence solvent, polymer concentration, processing parameters, such as applied voltage, flow rate, needle tip-collector distance. Scaffolds obtained under most favorable conditions were characterized in terms crystallinity, lamellar supramolecular order, thermal (including calorimetric thermogravimetric data), mechanical, surface properties. Results pointed out significant differences with respect to commercial sutures (based P4HB, e.g., MonoMax®) demonstrated that electrospun constituted by crystalline microfibers a tangled distribution leads high modulus Young (4 MPa), maximum strength (28 elongation (360%). Furthermore, new had stability rough led hydrophobic character (105°). could also be successfully loaded during electrospinning process peptide analog fibroblast growth factor (e.g., CYRSRKYSSWYVALKRC), giving rise fully samples clear acceleration wound healing.